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Gimme a brake: HPK1 regulates LFA-1 and neutrophil traction.

Abstract
In this issue of Blood, Jakob et al report that hematopoietic progenitor kinase 1 (HPK1) participates during signaling of neutrophil recruitment by acting as a regulator of the adhesiveness of the b2-integrin lymphocyte function-associated antigen 1 (LFA-1) during acute inflammation.
AuthorsScott I Simon
JournalBlood (Blood) Vol. 121 Issue 20 Pg. 4017-8 (May 16 2013) ISSN: 1528-0020 [Electronic] United States
PMID23682030 (Publication Type: Journal Article, Comment)
Chemical References
  • Lymphocyte Function-Associated Antigen-1
  • hematopoietic progenitor kinase 1
  • Protein Serine-Threonine Kinases
Topics
  • Acute-Phase Reaction (genetics)
  • Animals
  • Humans
  • Inflammation (genetics)
  • Lymphocyte Function-Associated Antigen-1 (physiology)
  • Neutrophil Infiltration (genetics)
  • Protein Serine-Threonine Kinases (physiology)

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