Abstract |
[V(V)O2(O2C14H6O2)(C5N2H12)](C5N2H13)(CH3OH) (1) and {Na[V(V)O(O2C14H6O2)2][(CH3)2NCHO]}n (2) have been synthesized by the reaction of V2O5 and NaVO3 with aromatic 1,2-diol (1,2-dihydroxyanthraquinone), and their molecular and crystal structures have been determined by X-ray diffraction. MTT assay tests of the V(V)O2L(A)L(B) and V(V)OL2 complexes against cancer cells have revealed that, when L is catechol, VOL2 showed broad-spectrum, high anticancer activities which were proportional to their concentration; however when L is naphthol or alizarin, VOL2 displayed little effect towards the cancer cells; moreover, complex 1 in the coordination model of V(V)O2L(A)L(B) showed specifically higher inhibition (88.65%) against HCT-8 than the clinical anticancer drug Fu-5 (69.97%). The results revealed that both the V(V) and the ligands cannot influence the inhibition against cancer cells individually. The mechanism of the broad-spectrum anticancer activities of VOL2 when L is catechol ligand might originate from the redox activities of V(V)/V(IV) which regulate the concentration of ROS ( reactive oxygen species). N-Methylpiperazine formed as a by-product in complex 1 was confirmed by (1)H NMR and its formation mechanism catalyzed by V2O5 has been deduced.
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Authors | Shizhen Du, Jun Feng, Xiaoming Lu, Guo Wang |
Journal | Dalton transactions (Cambridge, England : 2003)
(Dalton Trans)
Vol. 42
Issue 26
Pg. 9699-705
(Jul 14 2013)
ISSN: 1477-9234 [Electronic] England |
PMID | 23680987
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anthraquinones
- Antineoplastic Agents
- Organometallic Compounds
- Vanadium
- alizarin
- Fluorouracil
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Topics |
- Anthraquinones
(chemistry)
- Antineoplastic Agents
(chemical synthesis, chemistry, pharmacology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Fluorouracil
(pharmacology)
- Humans
- Models, Molecular
- Molecular Structure
- Organometallic Compounds
(chemical synthesis, chemistry, pharmacology)
- Structure-Activity Relationship
- Vanadium
(chemistry)
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