Abstract | OBJECTIVE: This study aimed to clarify the efficacy of 2 therapies for patients with severe acute organophosphorus pesticide poisoning, including atropine adverse effects, the length of intensive care unit (ICU) stay, complications, and mortality. METHODS: RESULTS: The total dose of atropine was 57.40 ± 15.14 mg in group A and 308.26 ± 139.16 mg in group B; group A received less atropine than did group B (P = .001). The length of ICU stay in group A was reduced (P = .025), and group A had fewer atropine adverse effects (P = .002). However, there was no significant difference in the mortality or complication rate between the 2 groups (P > .05). CONCLUSION: In patients with severe poisoning, group A used less atropine, had fewer atropine adverse effects, and had a shorter ICU stay. We suggest that therapy should be started as early as possible using a sufficient amount of pralidoxime chloride started intramuscularly in combination with atropine and that the drugs should not be prematurely discontinued.
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Authors | Xue Tang, Ruilan Wang, Hui Xie, Jiachang Hu, Wenbiao Zhao |
Journal | The American journal of emergency medicine
(Am J Emerg Med)
Vol. 31
Issue 6
Pg. 946-9
(Jun 2013)
ISSN: 1532-8171 [Electronic] United States |
PMID | 23680326
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Antidotes
- Pralidoxime Compounds
- Atropine
- pralidoxime
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antidotes
(administration & dosage, adverse effects, therapeutic use)
- Atropine
(administration & dosage, adverse effects, therapeutic use)
- Drug Therapy, Combination
- Female
- Humans
- Injections, Intramuscular
- Intensive Care Units
(statistics & numerical data)
- Length of Stay
- Male
- Middle Aged
- Organophosphate Poisoning
(drug therapy, mortality)
- Pralidoxime Compounds
(administration & dosage, adverse effects, therapeutic use)
- Retrospective Studies
- Young Adult
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