Protective effect of eicosapentaenoic acid-docosahexaenoic acid and alpha-linolenic acid rich phytosterol ester on brain antioxidant status and brain lipid composition in hypercholesterolemic rats.

Abstract

With a view to investigate the ameliorative effects of sitosterol esters against degenerative effects of hypercholesterolemia brain antioxidant enzyme assays, brain lipid profile, brain phospholipid compositional change and brain neurotransmitter concentrates (glutamic acid, asparctic acid, glycine) were measured in hypercholesterolemic rats. The results indicated that phytosterol esters have a role in countering hypercholesterolemia-related changes in the brain by decreasing the cholesterol levels, increasing the phospholipid levels and increasing the level of antioxidant enzymes. The results suggest that phytosterol esters may be of therapeutic significance and may offer new and effective options for the treatment of hypercholesterolemia-induced changes in the brain.

• Authors: Avery Sengupta, Mahua Ghosh
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 51 Issue 3 Pg. 241-8 (Mar 2013) ISSN: 0019-5189 [Print] India
• PMID: 23678545 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Antioxidants
• Esters
• Fish Oils
• Neurotransmitter Agents
• Phytosterols
• Sitosterols
• alpha-Linolenic Acid
• Docosahexaenoic Acids
• Eicosapentaenoic Acid
• Glutathione

Topics

• Amino Acids (metabolism)
• Animals
• Antioxidants (metabolism)
• Brain (drug effects, metabolism)
• Chromatography
• Docosahexaenoic Acids (metabolism)
• Eicosapentaenoic Acid (metabolism)
• Esters (pharmacology)
• Fish Oils (metabolism)
• Glutathione (metabolism)
• Hypercholesterolemia (metabolism)
• Male
• Neurotransmitter Agents (metabolism)
• Phytosterols (pharmacology)
• Rats
• Rats, Wistar
• Sitosterols (pharmacology)
• alpha-Linolenic Acid (metabolism)