Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to sarcoidosis: A meta-analysis.

Abstract

INTRODUCTION:

The purpose of this study was to examine whether the insertion (I) or deletion (D) of angiotensin-converting enzyme (ACE) polymorphism confers susceptibility to sarcoidosis.

METHODS:

A meta-analysis on the associations between the ACE I/D polymorphism and sarcoidosis was conducted.

RESULTS:

Seventeen comparison studies consisting of 1556 cases and 2381 controls were available for the meta-analysis. Meta-analysis revealed a significant association between the D allele and sarcoidosis (OR 1.206, 95% CI 1.049-1.386, p = 0.009). An ethnicity-specific meta-analysis of the DD+ID genotype showed an association with sarcoidosis in East Asians (OR 1.342, 95% CI 1.041-1.729, p = 0.023). An association was found between the DD genotype of the ACE I/D polymorphism and sarcoidosis (OR 1.251, 95% CI 1.070-1.463, p = 0.005). Furthermore, stratification by ethnicity indicated an association between the DD genotype and sarcoidosis in Europeans (OR = 1.215, 95% CI = 1.010-1.462, p = 0.039).

CONCLUSIONS:

Our meta-analysis demonstrates that the ACE I/D polymorphism is associated with susceptibility to sarcoidosis in European and East Asian populations.

• Authors: Gwan Gyu Song, Jae-Hoon Kim, Young Ho Lee
• Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS (J Renin Angiotensin Aldosterone Syst) Vol. 16 Issue 1 Pg. 219-26 (Mar 2015) ISSN: 1752-8976 [Electronic] England
• PMID: 23676252 (Publication Type: Journal Article, Meta-Analysis, Review)
• Copyright: © The Author(s) 2013.

Chemical References

• ACE protein, human
• Peptidyl-Dipeptidase A

Topics

• Alleles
• Gene Deletion
• Genotype
• Humans
• Mutagenesis, Insertional
• Peptidyl-Dipeptidase A (genetics)
• Polymorphism, Genetic (genetics)
• Sarcoidosis (epidemiology, genetics)