Abstract | BACKGROUND:
Poly (ADP-ribose) polymerase (PARP) has been proposed to play an important role in the pathogenesis of heart ischaemia/reperfusion (I/R) injury. 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone (DPQ), a potent PARP inhibitor, has cardiac protective effects. Because the underlying mechanisms are not understood, we investigated the effect of DPQ on heart I/R injury and its mechanisms. METHODS: RESULTS: Administration of DPQ significantly decreased the activation of PARP and cellular apoptosis from (35 ± 5)% to (20 ± 4)% and simultaneously improved the cardiac function. DPQ reduced the expressions of NF-κB, ICAM-1, COX-2 and MMP-9 in rat heart and facilitated the activations of phosphor-Akt, phosphor-GSK-3β and phosphor-FOXO3a. CONCLUSION: The protective effects of DPQ were associated with the suppression of inflammation and the activation of the Akt signalling pathways suggesting that the inhibition of poly (ADP-ribose) polymerase reduced heart I/R injury in rats.
|
Authors | Zhao-Feng Song, Dong-Yu Chen, Bo DU, Xiao-Ping Ji |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 126
Issue 10
Pg. 1913-7
( 2013)
ISSN: 2542-5641 [Electronic] China |
PMID | 23673109
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Enzyme Inhibitors
- Isoquinolines
- Piperidines
- Poly(ADP-ribose) Polymerase Inhibitors
- 3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoquinolinone
- Proto-Oncogene Proteins c-akt
|
Topics |
- Animals
- Blotting, Western
- Enzyme Inhibitors
(therapeutic use)
- Female
- Isoquinolines
(therapeutic use)
- Myocardial Reperfusion Injury
(drug therapy)
- Piperidines
(therapeutic use)
- Poly(ADP-ribose) Polymerase Inhibitors
- Proto-Oncogene Proteins c-akt
(metabolism)
- Rats
- Rats, Wistar
|