Abstract | PURPOSE: To evaluate results of QFT-2G/TBGL/ LAM in patients who had been completed the antituberculosis treatment for osteoarticular tuberculosis with various periods after the completion of the treatment, MATERIALS AND METHODS: Fifty-five patients who had been completed the antituberculosis treatment for osteoarticular tuberculosis at least one year after the completion of treatment were evaluated using QFT-2G/TBGL/ LAM tests. Forty patients with spinal tuberculosis and 15 patients with articular tuberculosis were included. The patients with the period after the completion of the treatment less than 4 years were classifled as short-term group (33 patients) and those with the period not less than 4 years were classified as mid-long-term group (22 patients). The results of the tests were compared between the two groups. RESULTS: The result of QFT-2G test was positive in 60.6% of the patients in short-term group while 45.5% in mid-long-term group (p=0.12). On the other hand, the result of TBGL test was positive in 75.8% of the patients in short-term group whereas 22.7% in mid-long-term group (p=0.0001) and the result of LAM test was positive in 90.9% of the patients in short-term group whereas 63.6% in mid-long-term group (p= 0.01), both of these tests showed significantly low,er positive rate in mid-long-term group. There was no significant difference in the comparisons between patient groups writh/without pulmonary tuberculosis as well as with/without surgical treatment. CONCLUSION: The patients with a history of osteoarticular tuberculosis tend to show positive results of QFT-2-G test for a prolonged period, whereas significantly less positive results of TBGL/ LAM tests in mid-long-term.
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Authors | Kazutaka Izawa |
Journal | Kekkaku : [Tuberculosis]
(Kekkaku)
Vol. 88
Issue 3
Pg. 277-81
(Mar 2013)
ISSN: 0022-9776 [Print] Japan |
PMID | 23672167
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Glycolipids
- Lipopolysaccharides
- lipoarabinomannan
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Female
- Glycolipids
(blood, immunology)
- Humans
- Interferon-gamma Release Tests
- Lipopolysaccharides
(blood)
- Male
- Middle Aged
- Mycobacterium tuberculosis
(immunology)
- Tuberculosis, Osteoarticular
(blood, drug therapy)
- Tuberculosis, Spinal
(blood, drug therapy)
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