Abstract | OBJECTIVE: METHODS: RESULTS: The remission (≤ 7 points on the 17-item Hamilton Depression Rating Scale) after 8 weeks of treatment was obtained in four female patients (50%). Of them, three still require other psychotropic medications to remain in remission and all four responders have been in remission with ongoing treatment with tianeptine for > 2 years. In two patients, the drug was terminated due to the incidence of delirium, and in one, it was due to severe agitation. CONCLUSION: The results may suggest a possible usefulness of tianeptine in selected patients with TRD. They also point to a possible serious side effect of this drug not hitherto reported.
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Authors | Edward H Tobe, Janusz K Rybakowski |
Journal | International journal of psychiatry in clinical practice
(Int J Psychiatry Clin Pract)
Vol. 17
Issue 4
Pg. 313-6
(Oct 2013)
ISSN: 1471-1788 [Electronic] England |
PMID | 23668804
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antidepressive Agents, Tricyclic
- Thiazepines
- tianeptine
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Topics |
- Adult
- Aged
- Akathisia, Drug-Induced
- Antidepressive Agents, Tricyclic
(adverse effects, pharmacology, therapeutic use)
- Delirium
(chemically induced)
- Depressive Disorder, Treatment-Resistant
(drug therapy)
- Drug Approval
- Drug Therapy, Combination
- Female
- Humans
- Male
- Middle Aged
- Psychiatric Status Rating Scales
- Remission Induction
(methods)
- Thiazepines
(adverse effects, pharmacology, therapeutic use)
- Treatment Outcome
- United States
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