Induction of chromosomal aberrations in male mouse germ cells by uranyl fluoride containing enriched uranium.

Abstract

Cytogenetic damage induced by a wide range of concentrations of uranyl fluoride injected into mouse testes was evaluated by determining the frequencies of chromosomal aberrations in spermatogonia and primary spermatocytes. Breaks, gaps and polyploids were observed in spermatogonia. The frequencies of the significant type of aberration, breaks, were induced according to the injected doses of uranyl fluoride. Primary spermatocytes were examined for fragments, univalents and multivalents. The multivalents observed in this study resulted either from chromatid interchanges or from reciprocal translocations. The reciprocal translocations were induced in spermatogonia and recorded in primary spermatocytes. For primary spermatocytes the incidence of aberrant cells largely depended on the administered dose. Sampling time after treatment could affect the frequencies of chromosomal aberrations in male mouse germ cells.

• Authors: Q Y Hu, S P Zhu
• Journal: Mutation research (Mutat Res) Vol. 244 Issue 3 Pg. 209-14 (Jul 1990) ISSN: 0027-5107 [Print] Netherlands
• PMID: 2366813 (Publication Type: Journal Article)

Chemical References

• Mutagens
• Uranium Compounds
• uranyl fluoride
• Uranium
• Fluorides

Topics

• Animals
• Chromosome Aberrations
• Fluorides
• Male
• Mice
• Mice, Inbred BALB C
• Mutagens
• Spermatocytes (drug effects, ultrastructure)
• Spermatogonia (drug effects, ultrastructure)
• Spermatozoa (drug effects)
• Testis (drug effects, ultrastructure)
• Uranium (toxicity)
• Uranium Compounds