[Clinical study of decoction of invigorating Qi and clearing lung combined standardized myrtol on acute exacerbation of chronic obstructive pulmonary disease (AECOPD)].

Abstract

OBJECTIVE:

To investigate the clinical effect of decoction of invigorating Qi and clearing lung combined standardized myrtol on acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

METHOD:

Ninety and eight patients with AECOPD patients were randomly divided into the treatment group and the control group, with 50 cases and 48 cases respectively. All the patients were given the conventional treatment. The control group was treated by standardized myrtol with 3 times a day, 300 mg each time taken orally. The treatment group was given decoction of invigorating Qi and clearing lung with 2 times a day, one dose per day taken orally, combined standardized myrtol (usage as above). After Two weeks, the scores of clinical symptom, blood gas analysis and pulmonary function were observed.

RESULT:

Both FEV1 and FEV1% were raised in the two groups after treating. And the treatment group was significantly higher than control group (P < 0.01). PaO2 and PaO2/FiO2 rose, with PaCO2 decreased in the two groups (P < 0.01). PaO2 and PaO2/FiO2 were significantly improved, and PaCO2 was significantly decreased in the treatment group compared to the control group (P < 0.01). In the clinical curative effect comparison aspects, clinical control rates were 42.0% in treatment group and 20.83% in control group respectively, with significant difference between the two groups (P < 0.05). Significant efficiency is 86.0% in treatment group and 52.08% in control group respectively, with significant difference between the two groups (P < 0.01).

CONCLUSION:

Decoction of invigorating Qi and clearing lung combined with standardized myrtol can obviously improve clinical symptom, blood gas an analysis and pulmonary function in patients with AECOPD.

• Authors: Zhao-Quan Hua, Yi-Jie Chang
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 38 Issue 3 Pg. 440-2 (Feb 2013) ISSN: 1001-5302 [Print] China
• PMID: 23668026 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Drug Combinations
• Monoterpenes
• myrtol

Topics

• Aged
• Blood Gas Analysis
• Drug Combinations
• Drug Therapy, Combination
• Female
• Humans
• Lung (physiopathology)
• Male
• Medicine, Chinese Traditional (methods)
• Middle Aged
• Monoterpenes (standards, therapeutic use)
• Pulmonary Disease, Chronic Obstructive (blood, physiopathology, therapy)
• Reference Standards
• Respiratory Function Tests
• Treatment Outcome