Protective effects of gallium, germanium, and strontium against ovariectomized osteoporosis in rats.

Abstract

The effects of trace elements of gallium (Ga), germanium (Ge), and strontium (Sr) on ovariectomized (OVX) osteopenic rats were studied in this paper. The urine calcium content, serum calcium, and phosphorus contents, bone mineral content, mineral dissolution, and mechanical strength of the osteopenic rats were analyzed respectively. After the rats were fed with Ga, Ge, and Sr diet for 8 weeks, respectively, the urine calcium content decreased (P < 0.01). Plasma calcium and phosphate concentrations decreased in the order of OVX group > Ge group > Sr group > Ga group > Sham group. Mineral content increased in the order of OVX group < Ge group < Sr group < Ga group < Sham group. A dramatic decrease in calcium solubility was found both in the gallium and strontium treated animals (P < 0.05). However, the same result did not occur in germanium treated groups. The data provide an important proof of concept that gallium and strontium might be a new potential therapy for the management of postmenopausal osteoporosis in humans.

• Authors: Da-wei Qin, Zhengwei Gu, Long Dai, Chao Ji
• Journal: Biological trace element research (Biol Trace Elem Res) Vol. 153 Issue 1-3 Pg. 350-4 (Jun 2013) ISSN: 1559-0720 [Electronic] United States
• PMID: 23666747 (Publication Type: Journal Article)

Chemical References

• Germanium
• Gallium
• Strontium

Topics

• Animals
• Female
• Gallium (therapeutic use)
• Germanium (therapeutic use)
• Osteoporosis (etiology, prevention & control)
• Ovariectomy
• Rats
• Rats, Wistar
• Strontium (therapeutic use)