In this study, the
analgesic effects of
dexketoprofen trometamol and
meperidine hydrochloride were compared in patients diagnosed with
renal colic. This study was a prospective, randomized, double-blind study. Fifty-two patients, between the ages of 18 and 70 years who were diagnosed with
renal colic, were enrolled in the study after obtaining ethics committee approval. Before
drug injection,
dexketoprofen trometamol and
meperidine hydrochloride were placed in closed envelopes, and the patients were randomly given a single dose of
intravenous infusion for 20 minutes. Severity of
pain and symptoms was evaluated with the numerical rating scale and
renal colic symptom score for each patient immediately before administration of drugs and 30 minutes after the end of the application. At the same time, systolic arterial blood pressure, diastolic arterial pressure, respiratory rate, heart rate,
nausea,
vomiting, and reactions due to
drug administration were recorded before and after
drug administration. In statistical methods, t test, analysis of variance, and repeated measure analysis were used for the analysis of normally distributed continuous variables and the Mann-Whitney U, Kruskal-Wallis and Friedman tests were used for analysis of not-normally distributed continuous variables. In the analysis of discrete variables, the χ test was used. In both groups, a significant decrease was found in numerical rating scale values measured 30 minutes after
drug administration, but the decline in
dexketoprofen trometamol group (P = 0.02) was found to be more. Although a significant decrease was found in the
renal colic symptom score (P < 0.001) values measured after
drug administration in the
dexketoprofen trometamol group, no significant decrease was found in the
meperidine HCl (P = 0.058) group. After
drug administration, a statistically significant decrease was found in the systolic arterial blood pressure, heart rate, and respiratory rate in both groups. Also, a statistically significant decrease was found in the diastolic arterial pressure in the
meperidine group. But these changes in vital findings were not serious enough to disrupt patients' clinical status. With this study, we concluded that
dexketoprofen trometamol, from the nonsteroidal anti-inflammatory
drug group, can be within the primary treatment options for
renal colic because of better
analgesic efficacy, being well tolerated by patients compared with
meperidine hydrochloride.