Abstract | OBJECTIVES: MATERIALS AND METHODS: Quantitative RT-PCR and immunohistochemistry (IHC) were used to determine the expression of USP22 protein in 44 SDCs in comparison with 20 non-cancerous salivary tissues. Furthermore, we analyzed the correlation between the expression of the USP22 protein and various clinicopathologic factors including survival status of patients with SDC. RESULTS: The incidence of positive USP22 expression was 63.7% in 44 SDC tissues. The mRNA level of USP22 expression in SDC samples was significantly higher than that in non-cancerous salivary tissues (P < 0.001), which was consistent with the IHC result (P < 0.001). Moreover, statistical analysis showed that positive USP22 expression was positively related to pT classification, pN classification and AJCC stage. Notably, high USP22 expression was significantly associated with shorter overall survival (P = 0.023) and disease-specific survival (P = 0.019). Multivariate Cox regression analysis revealed that USP22 expression level was an independent prognostic factor for both overall survival (P < 0.001) and disease-free survival (P < 0.001). CONCLUSION: Our results indicate that activation of USP22 correlates with SDC progression and therapy failure. Overexpression of USP22 may contribute to the progression of SDC and thus may serve as a new molecular marker to predict the prognosis of SDC patients.
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Authors | Songlin Piao, Jie Ma, Wei Wang, Yanlong Liu, Minghui Zhang, Hongying Chen, Feng Guo, Bin Zhang, Fulin Guo |
Journal | Oral oncology
(Oral Oncol)
Vol. 49
Issue 8
Pg. 796-801
(Aug 2013)
ISSN: 1879-0593 [Electronic] England |
PMID | 23664741
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013. Published by Elsevier Ltd. |
Chemical References |
- Biomarkers, Tumor
- Thiolester Hydrolases
- Ubiquitin Thiolesterase
- Usp22 protein, human
|
Topics |
- Biomarkers, Tumor
(metabolism)
- Disease Progression
- Female
- Humans
- Male
- Middle Aged
- Prognosis
- Salivary Ducts
(pathology)
- Salivary Gland Neoplasms
(metabolism, pathology)
- Thiolester Hydrolases
(metabolism)
- Treatment Outcome
- Ubiquitin Thiolesterase
|