AA amyloidosis associated with systemic-onset juvenile idiopathic arthritis.

Abstract

We report a 12-year-old boy with nephrotic syndrome due to renal AA amyloidosis. The AA amyloidosis was associated with a 3-year history of systemic-onset juvenile idiopathic arthritis. The presence of serum amyloid A protein was confirmed by laser microdissection of Congo Red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry; this analysis excluded hereditary and familial amyloidosis. Aggressive management of the systemic-onset juvenile idiopathic arthritis resulted in improvement in clinical and laboratory parameters. The case represents an unusual cause of nephrotic syndrome in children. Early diagnosis of renal amyloidosis and management of systemic-onset juvenile idiopathic arthritis is paramount to preventing progression of kidney disease.

• Authors: Abhijeet Saha, Yogiraj Chopra, Jason D Theis, Julie A Vrana, Sanjeev Sethi
• Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation (Am J Kidney Dis) Vol. 62 Issue 4 Pg. 834-8 (Oct 2013) ISSN: 1523-6838 [Electronic] United States
• PMID: 23664546 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Chemical References

• Serum Amyloid A Protein

Topics

• Amyloidosis (complications)
• Arthritis, Juvenile (complications)
• Child
• Humans
• Male
• Nephrotic Syndrome (etiology)
• Serum Amyloid A Protein