Abstract | BACKGROUND AND OBJECTIVES: MATERIALS AND METHODS:
Asthma was induced by ovalbumin (OVA) sensitization and challenge. Then mice were treated with normal saline or hydrogen-rich saline at low and high doses. Cell counts and cytokine levels in bronchoalveolar lavage fluid (BALF) were determined, bronchial tissue was analyzed for pathology, and expression of MUC5AC, collagen III, VEGF, and total and phosphorylated NF-κB p65 was measured. Immunohistochemistry was used to identify levels and localization of VEGF expression in lung. RESULTS: CONCLUSIONS:
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Authors | M Xiao, T Zhu, T Wang, F-Q Wen |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
Vol. 17
Issue 8
Pg. 1033-43
(Apr 2013)
ISSN: 1128-3602 [Print] Italy |
PMID | 23661516
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- NF-kappa B
- Sodium Chloride
- Hydrogen
- Ovalbumin
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Topics |
- Airway Remodeling
- Animals
- Asthma
(drug therapy)
- Bronchoalveolar Lavage Fluid
(immunology)
- Cytokines
(analysis)
- Disease Models, Animal
- Female
- Hydrogen
(therapeutic use)
- Mice
- Mice, Inbred BALB C
- NF-kappa B
(antagonists & inhibitors)
- Ovalbumin
(immunology)
- Sodium Chloride
(therapeutic use)
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