Abstract |
The design, synthesis, and development of INDQ/NO, a novel nitric oxide (NO) prodrug targeted by a bioreductive trigger, are described. INDQ/NO, an indolequinone- diazeniumdiolate is found to be metabolized to produce NO by DT-diaphorase, a bioreductive enzyme that is overexpressed in certain cancers and hypoxic tumors. Cell-based assays revealed that INDQ/NO induces DNA damage and is a potent inhibitor of cancer cell proliferation.
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Authors | Kavita Sharma, Aishwarya Iyer, Kundan Sengupta, Harinath Chakrapani |
Journal | Organic letters
(Org Lett)
Vol. 15
Issue 11
Pg. 2636-9
(Jun 07 2013)
ISSN: 1523-7052 [Electronic] United States |
PMID | 23659457
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Aziridines
- Indolequinones
- Prodrugs
- Nitric Oxide
- NAD(P)H Dehydrogenase (Quinone)
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Topics |
- Antineoplastic Agents
(chemistry, pharmacology)
- Aziridines
(chemical synthesis, chemistry)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Drug Design
- Humans
- Indolequinones
(chemical synthesis, chemistry, pharmacology)
- NAD(P)H Dehydrogenase (Quinone)
(chemistry, metabolism, pharmacology)
- Nitric Oxide
(chemistry, metabolism, pharmacology)
- Prodrugs
(chemical synthesis, chemistry)
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