Cytotoxic constituents from Psoralea corylifolia.

Abstract

Bioassay directed isolation of the EtOAc extract from a traditional Chinese medicine Psoralea corylifolia resulted in the purification of two isoflavonoids, corylifols D (1) and E (2), along with four known ones. The structures of 1 and 2 were determined by extensive 1D and 2D NMR and MS data analyses. When tested against HepG2 and Hep3B hepatocellular carcinoma cell lines, corylifol A (4) displayed IC50 values of 4.6 and 13.5 μg/ml, respectively.

• Authors: Ping Song, Xin-Zhou Yang, Jing-Quan Yuan
• Journal: Journal of Asian natural products research (J Asian Nat Prod Res) Vol. 15 Issue 6 Pg. 624-30 ( 2013) ISSN: 1477-2213 [Electronic] England
• PMID: 23659434 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Drugs, Chinese Herbal
• Furocoumarins
• Isoflavones
• corylifol D
• corylifol E

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Drug Screening Assays, Antitumor
• Drugs, Chinese Herbal (chemistry, isolation & purification, pharmacology)
• Furocoumarins (chemistry)
• Hep G2 Cells
• Humans
• Inhibitory Concentration 50
• Isoflavones (chemistry, isolation & purification, pharmacology)
• Medicine, Chinese Traditional
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Psoralea (chemistry)
• Seeds (chemistry)