Morphological study of burn wound healing with the use of collagen-chitosan wound dressing.

Abstract

Experiments on the model of thermal skin burn in rats showed that the use of wound dressing based on collagen-chitosan complex Kollakhit-Bol in local treatment of grade IIIb skin burns increased healing rate by accelerating the formation of granulation and fibrous connective tissues and reducing crust thickness in comparison with Kollakhit coating. Kollakhit-Bol provided targeted stimulation of reparative processes in the treatment of grade IIIb burns by creating favorable conditions for grafting full thickness skin transplant or dermal-epidermal skin equivalent. In the topical treatment of thermal burn, Kollakhit-Bol application shortened the phases of alteration and exudation and accelerated transition to the productive phase of the inflammatory process with phagocytosis and neoangiogenesis activation.

• Authors: A K Kirichenko, I N Bolshakov, A E Ali-Riza, A A Vlasov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 154 Issue 5 Pg. 692-6 (Mar 2013) ISSN: 1573-8221 [Electronic] United States
• PMID: 23658900 (Publication Type: Journal Article)

Chemical References

• Collagen
• Chitosan

Topics

• Animals
• Bandages
• Burns (therapy)
• Chitosan
• Collagen
• Connective Tissue
• Granulation Tissue
• Inflammation (drug therapy)
• Male
• Rats
• Rats, Wistar
• Skin Transplantation
• Wound Healing