Involvement of translation and transcription processes into neurophysiological mechanisms of long-term memory reconsolidation.

Abstract

We studied the involvement of translation and transcription processes into behavioral and neuronal mechanisms of reconsolidation of the long-term memory of the conditioned taste aversion in edible snails. Injection of cycloheximide (an inhibitor of protein synthesis) to the snails in 48 h after training combined with subsequent reminder and presentation of the conditional stimulus resulted in the development of persistent amnesia and depression of the responses of the defensive behavior command neurons LPl1 and RPl1 to the conditional stimulus. Injection of mRNA synthesis inhibitors actinomycin D or DRB (5,6-dichloro-1-β-D-ribofuranosylbenzimidasole) in 48 h after conditioning with subsequent reminding procedure produced no effects on memory retention and on the responses of the command neurons to the conditional stimulus. The study suggests that the proteins translated from previously synthesized and stored mRNA were involved in the mechanisms of reconsolidation of the memory responsible for conditioned taste aversion.

• Authors: S A Kozyrev, V P Nikitin
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 154 Issue 5 Pg. 584-7 (Mar 2013) ISSN: 1573-8221 [Electronic] United States
• PMID: 23658873 (Publication Type: Journal Article)

Chemical References

• Enzyme Inhibitors
• Protein Synthesis Inhibitors
• RNA, Messenger
• RNA, Messenger, Stored
• Dactinomycin
• Dichlororibofuranosylbenzimidazole
• Cycloheximide

Topics

• Animals
• Avoidance Learning
• Conditioning, Classical
• Cycloheximide (pharmacology)
• Dactinomycin (pharmacology)
• Dichlororibofuranosylbenzimidazole (pharmacology)
• Enzyme Inhibitors (pharmacology)
• Helix, Snails (drug effects, genetics, physiology)
• Memory, Long-Term (drug effects, physiology)
• Protein Biosynthesis
• Protein Synthesis Inhibitors (pharmacology)
• RNA, Messenger (genetics, metabolism)
• RNA, Messenger, Stored (genetics, metabolism)
• Taste
• Transcription, Genetic