Suppression of TLR-4-related inflammatory pathway and anti-fibrosis effects of probiotic-fermented purple sweet potato yogurt in hearts of spontaneously hypertensive rats.
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| Abstract |
Inflammation plays an important role in triggering fibrosis of cardiovascular disease and hypertension. Gamma-aminobutyric acid (GABA) has hypotensive effect; GABA concentration could be enhanced in milk fermented with lactic acid bacteria (LAB). This study evaluated the effect of probiotic-fermented purple sweet potato yogurt (PSPY) on the toll-like receptor 4 (TLR-4)-related inflammatory components, and on fibrosis in the heart of spontaneously hypertensive rat (SHR). TLR4-related pathway and fibrosis-associated proteins TGFbeta and FGF2 were significantly increased in SHR hearts, but were highly suppressed in 10% PSPY-fed rats. Microscopic examination with Masson trichrome staining of left ventricle further demonstrated that 10% and 100% PSPY both significantly reduced interstitial fibrosis in SHR hearts. These findings indicated that oral administration of 10% probiotic-fermented PSPY was strong enough to lower cardiac fibrosis in SHR rats through the suppression of TLR-4-related inflammatory pathway. Therefore, PSPY may be included in diets to help prevent cardiac fibrosis in patients with hypertension.
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| Authors | Pei-Pei Lin, You-Miin Hsieh, Wei-Wen Kuo, Yueh-Min Lin, Yu-Lan Yeh, Chien-Chung Lin, Fuu-Jen Tsai, Chang-Hai Tsai, Cheng-Chih Tsai, Chih-Yang Huang |
| Journal | The Chinese journal of physiology (Chin J Physiol) Vol. 56 Issue 3 Pg. 174-83 (Jun 30 2013) ISSN: 0304-4920 [Print] India |
| PMID | 23656219 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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