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Prolonged exposure to a low-dose of bisphenol A increases spontaneous motor activity in adult male rats.

Abstract
We investigated the effects of bisphenol A (BPA), an environmental endocrine-disrupting chemical, on spontaneous motor activity in adult male rats. The rats were implanted intraperitoneally with mini-osmotic pumps containing either BPA (50 μg/kg body weight per day) in sesame oil (BPA-treated group) or sesame oil only (vehicle-treated group). Spontaneous motor activity during a 24-h period was measured over 5 days from day 9 to day 13 after implantation using an animal movement analysis system. Spontaneous motor activity during the last 2 h of the dark phase and during the first 1-h of the light phase was increased in the BPA-treated group. Total spontaneous motor activity during the 12-h light phase, but not the 12-h dark phase, was higher in the BPA-treated group than in the vehicle-treated group. These findings suggest that BPA may induce hyperactivity in adult male rats during the 12-h light phase, especially during the 2 h immediately preceding sleep-onset and 1 h immediately following sleep-onset.
AuthorsKazuo Nojima, Tomoyo Takata, Hiroshi Masuno
JournalThe journal of physiological sciences : JPS (J Physiol Sci) Vol. 63 Issue 4 Pg. 311-5 (Jul 2013) ISSN: 1880-6562 [Electronic] Japan
PMID23653311 (Publication Type: Journal Article)
Chemical References
  • Benzhydryl Compounds
  • Phenols
  • bisphenol A
Topics
  • Animals
  • Benzhydryl Compounds (pharmacology)
  • Darkness
  • Hyperkinesis (chemically induced)
  • Light
  • Male
  • Motor Activity (drug effects)
  • Phenols (pharmacology)
  • Rats
  • Sleep (drug effects)

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