A pooled analysis of diagnostic value of (99m)Tc-ubiquicidin (UBI) scintigraphy in detection of an infectious process.

Abstract

PURPOSE:

Although the data are promising from limited studies with technetium-99m ubiquicidin (Tc-UBI) scintigraphy in detection of infection in humans, these studies have had a limited sample size. This study was conducted to provide a systematic review and meta-analysis of the reported diagnostic accuracy of Tc-UBI scintigraphy in detection of an infectious process.

MATERIALS AND METHODS:

The PubMed/MEDLINE, Web of Science, EMBASE, and Google Scholar literature databases were systematically searched to find the relevant human studies on Tc-UBI scintigraphy. For each eligible study, the true-positive, false-positive, true-negative, and false-negative findings at Tc-UBI scintigraphy were recorded, and the overall statistical parameters were acquired.

RESULT:

Ten studies carried out from 2004 to 2010 were included in the analysis. The pooled data sensitivity was 94.5 % and with a 95% confidence interval of 91.2%-96.8%. The pooled specificity was still as high as about 92.7%. The range of reported specificity was from 80% to 100%. The overall accuracy was 93.7% (95% CI: 91.2%-95.7%).

CONCLUSION:

The study demonstrated that Tc-UBI scintigraphy can be used to identify an infectious process with admirable accuracy in early views; however, further investigations are recommended.

• Authors: Afshin Ostovar, Mahsan Assadi, Katayoun Vahdat, Iraj Nabipour, Hamid Javadi, Mohammad Eftekhari, Majid Assadi
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 38 Issue 6 Pg. 413-6 (Jun 2013) ISSN: 1536-0229 [Electronic] United States
• PMID: 23652406 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)

Chemical References

• Organotechnetium Compounds
• Peptide Fragments
• technetium 99m ubiquicidin(29-41)

Topics

• Humans
• Infections (diagnostic imaging)
• Organotechnetium Compounds
• Peptide Fragments
• Radionuclide Imaging
• Sensitivity and Specificity