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Mast cell degranulating peptide induces the expression of the c-fos proto-oncogene in hippocampus.

AbstractThe intrahippocampal injection of the mast cell degranulating (MCD) peptide, a bee venom component acting on the K+ channel, results in the appearance of the proto-oncogene c-fos mRNA in the ipsi- and contralateral hippocampus of the treated animals without generating convulsions. This MCD-induced transcriptional event is discussed in terms of cellular plasticity since MCD peptide is known to induce long-term potentiation.
AuthorsJ M Séquier, M Lazdunski (Affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France.)
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 180 Issue 1 Pg. 179-81 (May 3 1990) ISSN: 0014-2999 [Print] NETHERLANDS
PMID2365001 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Peptides
  • RNA, Messenger
  • Sulfur Radioisotopes
  • mast cell degranulating peptide
Topics
  • Animals
  • Gene Expression (drug effects)
  • Hippocampus (anatomy & histology, metabolism)
  • Injections
  • Male
  • Peptides (pharmacology)
  • Proto-Oncogenes (drug effects)
  • RNA, Messenger (drug effects, genetics)
  • Rats
  • Rats, Inbred Strains
  • Sulfur Radioisotopes (diagnostic use)
  • Transcription, Genetic

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