Mast cell degranulating peptide induces the expression of the c-fos proto-oncogene in hippocampus.

Abstract

The intrahippocampal injection of the mast cell degranulating (MCD) peptide, a bee venom component acting on the K+ channel, results in the appearance of the proto-oncogene c-fos mRNA in the ipsi- and contralateral hippocampus of the treated animals without generating convulsions. This MCD-induced transcriptional event is discussed in terms of cellular plasticity since MCD peptide is known to induce long-term potentiation.

• Authors: J M Séquier, M Lazdunski
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 180 Issue 1 Pg. 179-81 (May 03 1990) ISSN: 0014-2999 [Print] Netherlands
• PMID: 2365001 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Peptides
• RNA, Messenger
• Sulfur Radioisotopes
• mast cell degranulating peptide

Topics

• Animals
• Gene Expression (drug effects)
• Hippocampus (anatomy & histology, metabolism)
• Injections
• Male
• Peptides (pharmacology)
• Proto-Oncogenes (drug effects)
• RNA, Messenger (drug effects, genetics)
• Rats
• Rats, Inbred Strains
• Sulfur Radioisotopes
• Transcription, Genetic