Neuregulin 3 and erbb signalling networks in embryonic mammary gland development.

Abstract

We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development. Neuregulins are growth factors that bind and activate its cognate Erbb receptor tyrosine kinases, which form a signalling network with established roles in breast development and breast cancer. Studies have shown that Nrg3 expression profoundly impacts early stages of embryonic mammary development. Network analysis shows how Nrg/Erbb signals could integrate with other major regulators of embryonic mammary development to elicit the morphogenetic processes and cell fate decisions that occur as the mammary lineage is established.

• Authors: Naoko Kogata, Marketa Zvelebil, Beatrice A Howard
• Journal: Journal of mammary gland biology and neoplasia (J Mammary Gland Biol Neoplasia) Vol. 18 Issue 2 Pg. 149-54 (Jun 2013) ISSN: 1573-7039 [Electronic] United States
• PMID: 23649700 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Neuregulins
• Oncogene Proteins v-erbB

Topics

• Animals
• Female
• Gene Expression Regulation, Developmental
• Humans
• Mammary Glands, Animal (embryology, metabolism)
• Mammary Glands, Human (embryology, metabolism)
• Neuregulins (genetics, metabolism)
• Oncogene Proteins v-erbB (genetics, metabolism)
• Signal Transduction