Abstract | BACKGROUND AND OBJECTIVE: MATERIAL AND METHODS: RESULTS:
EMMPRIN was expressed in gingival epithelial cells, inflammatory cells, endothelial and fibroblast-like cells. Strong caveolin-1 immunoreactivity was detected in gingival epithelial and endothelial cells. Double immunofluorescence studies revealed EMMPRIN and caveolin-1 co-localization in gingival epithelium, endothelial and fibroblast-like cells. Compared with healthy subjects, the chronic periodontitis group had increased high-glycoform EMMPRIN (HG- EMMPRIN) and active MMP-1 expression (p < 0.05). Active MMP-1 and proMMP-1 protein levels were positively correlated with HG- EMMPRIN levels (p < 0.05). CONCLUSION:
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Authors | J Wang, D Yang, C Li, S Shang, J Xiang |
Journal | Journal of periodontal research
(J Periodontal Res)
Vol. 49
Issue 2
Pg. 197-204
(Apr 2014)
ISSN: 1600-0765 [Electronic] United States |
PMID | 23647605
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- BSG protein, human
- Caveolin 1
- Basigin
- MMP1 protein, human
- Matrix Metalloproteinase 1
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Topics |
- Adolescent
- Adult
- Basigin
(analysis)
- Caveolin 1
(analysis)
- Chronic Periodontitis
(metabolism, pathology)
- Dental Plaque Index
- Endothelial Cells
(chemistry)
- Endothelium, Vascular
(chemistry)
- Epithelial Cells
(chemistry)
- Female
- Fibroblasts
(chemistry)
- Gingiva
(chemistry, cytology)
- Glycosylation
- Humans
- Male
- Matrix Metalloproteinase 1
(analysis)
- Middle Aged
- Periodontal Attachment Loss
(classification)
- Periodontal Index
- Periodontal Pocket
(classification)
- Young Adult
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