Abstract | AIMS:
Macelignan isolated from Myristica fragrans Houtt. is widely used for spice and flavoring for foods, and has been reported to have anti-inflammatory activity. The aim of this study was to investigate the effects of macelignan on allergic lung inflammation with a murine model of experimental asthma. MAIN METHODS: KEY FINDINGS: SIGNIFICANCE: Our data show that macelignan has anti-inflammatory effects on Th2 cell-mediated allergic lung inflammation and could potentially provide a novel preventative and/or therapy for the treatment of allergic diseases.
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Authors | Kihyuk Shin, Hee-Chul Chung, Do-Un Kim, Jae-Kwan Hwang, Seung-Hyo Lee |
Journal | Life sciences
(Life Sci)
Vol. 92
Issue 22
Pg. 1093-9
(Jun 13 2013)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 23643632
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- GATA3 Transcription Factor
- Gata3 protein, mouse
- Lignans
- Plant Extracts
- Interleukin-4
- macelignan
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Asthma
(chemically induced, drug therapy, physiopathology)
- Bronchial Hyperreactivity
(chemically induced, drug therapy, physiopathology)
- CD4-Positive T-Lymphocytes
(drug effects, metabolism)
- Disease Models, Animal
- Female
- GATA3 Transcription Factor
(metabolism)
- Interleukin-4
(metabolism)
- Lignans
(pharmacology)
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Myristica
(chemistry)
- Plant Extracts
(pharmacology)
- Th2 Cells
(drug effects, metabolism)
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