Abstract | BACKGROUND AND PURPOSE: METHODS: Prospective cohort of consecutive adults with spontaneous ICH. Incidence and predictors were identified with Cox regression. We included multivariate analyses on MRI biomarkers (global cortical atrophy, leukoaraiosis, brain microbleeds). RESULTS: Our study population consisted of 325 patients: 54% men, median age 70 years (interquartile range, 58-79). During 778 person-years of follow-up, the incidence rate was 4 new cases/100 person-years (95% confidence interval, 3-6). The median delay between ICH and LS was 9 months (interquartile range, 3-23). The only factor independently associated with the occurrence of LS was a cortical involvement of the ICH (hazard ratio, 2.8; 95% confidence interval, 1.3-6.1). Concerning MRI biomarkers, multivariate analyses found lobar brain microbleeds to be associated with LS (hazard ratio, 2.4; 95% confidence interval, 1.1-5.4), especially if ≥ 3 (hazard ratio, 2.7; 95% confidence interval, 1.1-6.8). LS were associated with a worse functional outcome after 3 years of follow-up (P=0.009). CONCLUSIONS: LS frequently occur >9 months after ICH onset, imposing a long-term follow-up. The association of lobar brain microbleeds with the risk of LS might suggest a link with the underlying vasculopathy ( cerebral amyloid angiopathy).
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Authors | Costanza Rossi, Veerle De Herdt, Nelly Dequatre-Ponchelle, Hilde Hénon, Didier Leys, Charlotte Cordonnier |
Journal | Stroke
(Stroke)
Vol. 44
Issue 6
Pg. 1723-5
(Jun 2013)
ISSN: 1524-4628 [Electronic] United States |
PMID | 23640832
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Cerebral Amyloid Angiopathy
(complications)
- Cerebral Hemorrhage
(epidemiology, mortality, pathology)
- Cohort Studies
- Female
- Follow-Up Studies
- Hemorrhage
(complications)
- Humans
- Incidence
- Kaplan-Meier Estimate
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Seizures
- Survival Rate
- Time Factors
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