A combination of a dairy product fermented by lactobacilli and galactooligosaccharides shows additive effects on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor.

Abstract	This study aimed to investigate the effects of a combination of a dairy product fermented by lactobacilli (DFL) and galactooligosaccharides (GOS) on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor (PPI). Three-week-old male rats were assigned to receive one of six diets: a control diet, control diets containing 1.6 or 5.0 % GOS, a DFL diet and DFL diets containing 1.6 or 5.0 % GOS for 9 days. From day 5 of the feeding period, half of the rats fed with control diets were subcutaneously administered with saline, whereas the remaining rats were administered with PPI for 5 days. Calcium (Ca), phosphorus (P), magnesium (Mg), iron (Fe) and zinc (Zn) balances were determined from days 6 to 9. PPI administration significantly decreased the apparent absorption of Ca and Fe and increased urinary P excretion, resulting in decreased Ca, Fe and P retention. GOS dose-dependently increased the apparent absorption of Ca, Mg and Fe and urinary Mg excretion and decreased urinary P excretion. DFL significantly increased the apparent absorption of Ca and Mg and urinary Mg excretion. The combination of DFL and GOS additively affected these parameters, resulting in increased Ca, P and Fe retention, and it further increased the apparent absorption and retention of Zn at 5.0 % GOS. In conclusion, the combination of DFL and GOS improves Ca, P and Fe retention in an additive manner and increases the Zn retention in growing rats with hypochlorhydria induced by PPI.
Authors	Satoshi Takasugi, Kinya Ashida, Suyaka Maruyama, Yukari Matsukiyo, Tetsuo Kaneko, Taketo Yamaji
Journal	Biological trace element research (Biol Trace Elem Res) Vol. 153 Issue 1-3 Pg. 309-18 (Jun 2013) ISSN: 1559-0720 [Electronic] United States
PMID	23640280 (Publication Type: Journal Article)
Chemical References	Oligosaccharides Proton Pump Inhibitors
Topics	Achlorhydria (chemically induced, drug therapy) Animals Bone Density Dairy Products Fermentation Lactobacillus (metabolism) Male Oligosaccharides (metabolism) Proton Pump Inhibitors (adverse effects, therapeutic use) Rats Rats, Sprague-Dawley Tomography, X-Ray Computed

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