Genetics of hypersensitivity to aspirin and nonsteroidal anti-inflammatory drugs.

Abstract

Various hypersensitivity reactions have been reported with aspirin and nonsteroidal anti-inflammatory drugs. Hypersensitivity can occur regardless of a chemical drug structure or its therapeutic potency. Allergic conditions include aspirin-exacerbated respiratory disease (AERD or aspirin-induced asthma), aspirin-induced urticaria/angioedema (AIU), and anaphylaxis. Several genetic studies on aspirin hypersensitivity have been performed to discover the genetic predisposition to aspirin hypersensitivity and to gain insight into the phenotypic diversity. This article updates data on the genetic mechanisms that govern AERD and AIU and summarizes recent findings on the molecular genetic mechanism of aspirin hypersensitivity.

• Authors: Seung-Hyun Kim, Marek Sanak, Hae-Sim Park
• Journal: Immunology and allergy clinics of North America (Immunol Allergy Clin North Am) Vol. 33 Issue 2 Pg. 177-94 (May 2013) ISSN: 1557-8607 [Electronic] United States
• PMID: 23639707 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Aspirin

Topics

• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Aspirin (adverse effects)
• Drug Hypersensitivity (genetics, immunology)
• Humans