Abstract |
Fullerene (C60) has shown great potential in drug delivery. In this study we exploited modified fullerene (diadduct malonic acid- fullerene- Asn-Gly-Arg peptide [DMA-C60-NGR]) as an antitumor drug carrier in order to build a new tumor-targeting drug delivery system. We also investigated the synergistic enhancement of cancer therapy using photodynamic therapy ( PDT) induced by DMA-C60-NGR and 2-methoxyestradiol (2ME). Cytotoxicity tests indicated that DMA-C60-NGR had no obvious toxicity, while our drug delivery system (DMA-C60-2ME-NGR) had a high inhibition effect on MCF-7 cells compared to free 2ME. The tumor-targeting drug delivery system could efficiently cross cell membranes, and illumination induced the generation of intracellular reactive oxygen species and DNA damage. Furthermore, DMA-C60-2ME-NGR with irradiation had the highest inhibition effect on MCF-7 cells compared to the other groups. DMA-C60-NGR combined with 2ME showed a good synergistic photosensitization effect for inhibiting the growth of MCF-7 cells, demonstrating that DMA-C60-2ME-NGR may be promising for high treatment efficacy with minimal side effects in future therapy.
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Authors | Jinjin Shi, Zhenzhen Wang, Lei Wang, Honghong Wang, Lulu Li, Xiaoyuan Yu, Jing Zhang, Rou Ma, Zhenzhong Zhang |
Journal | International journal of nanomedicine
(Int J Nanomedicine)
Vol. 8
Pg. 1551-62
( 2013)
ISSN: 1178-2013 [Electronic] New Zealand |
PMID | 23637528
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Carriers
- Fullerenes
- Malonates
- NGR peptide
- Oligopeptides
- Photosensitizing Agents
- Reactive Oxygen Species
- Estradiol
- 2-Methoxyestradiol
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Topics |
- 2-Methoxyestradiol
- Animals
- Apoptosis
(drug effects)
- Breast Neoplasms
(drug therapy, metabolism, pathology)
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- DNA Fragmentation
(drug effects)
- Drug Carriers
(administration & dosage, chemistry, pharmacokinetics)
- Estradiol
(administration & dosage, analogs & derivatives, chemistry)
- Female
- Fullerenes
(administration & dosage, chemistry, pharmacokinetics)
- Humans
- MCF-7 Cells
- Malonates
(administration & dosage, chemistry, pharmacokinetics)
- Mice
- Oligopeptides
(administration & dosage, chemistry, pharmacokinetics)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(administration & dosage, pharmacokinetics)
- Reactive Oxygen Species
(metabolism)
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