HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hypophosphatemic rickets due to perturbations in renal tubular function.

Abstract
The common denominator for all types of rickets is hypophosphatemia, leading to inadequate supply of the mineral to the growing bone. Hypophosphatemia can result from insufficient uptake of the mineral from the gut or its disproportionate losses in the kidney, the latter being caused by either tubular abnormalities per se or the effect on the tubule of circulating factors like fibroblast growth factor-23 and parathyroid hormone (PTH). High serum levels of the latter result in most cases from abnormalities in vitamin D metabolism which lead to decreased calcium absorption in the gut and hypocalcemia, triggering PTH secretion. Rickets is a disorder of the growth plate and hence pediatric by definition. However, it is important to recognize that the effect of hypophosphatemia on other parts of the skeleton results in osteomalacia in both children and adults. This review addresses the etiology, pathophysiologic mechanisms, clinical manifestations and treatment of entities associated with hypophosphatemic rickets due to perturbations in renal tubular function.
AuthorsMaria Goretti M G Penido, Uri S Alon
JournalPediatric nephrology (Berlin, Germany) (Pediatr Nephrol) Vol. 29 Issue 3 Pg. 361-73 (Mar 2014) ISSN: 1432-198X [Electronic] Germany
PMID23636577 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Phosphates
Topics
  • Age Factors
  • Genetic Predisposition to Disease
  • Growth Plate (metabolism, physiopathology)
  • Humans
  • Kidney Tubules, Proximal (metabolism, physiopathology)
  • Osteogenesis
  • Phosphates (metabolism)
  • Prognosis
  • Rickets, Hypophosphatemic (diagnosis, etiology, genetics, metabolism, physiopathology, therapy)
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: