Histidine-rich protein 2 plasma levels predict progression to cerebral malaria in Malawian children with Plasmodium falciparum infection.

Some children with uncomplicated malaria progress to cerebral malaria despite appropriate treatment; identifying them in advance might improve their care. The objective of this study was to determine if plasma concentrations of a malaria protein, HRP2 (histidine-rich protein 2) would serve this purpose. Cases and controls were children presenting with uncomplicated malaria; the cases (n = 25) developed cerebral malaria, and the controls (n = 125) did not. Mean plasma HRP2 concentrations were significantly higher in the cases, and an HRP2 cutoff was identified that could predict disease progression (sensitivity and specificity, 88% for each). Quantitative measurements of HRP2 may be a useful screening tool.
AuthorsLindsay L Fox, Terrie E Taylor, Paul Pensulo, Alice Liomba, Ashley Mpakiza, Amanda Varela, Simon J Glover, Mathew J Reeves, Karl B Seydel
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 208 Issue 3 Pg. 500-3 (Aug 1 2013) ISSN: 1537-6613 [Electronic] United States
PMID23630364 (Publication Type: Evaluation Studies, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Protozoan
  • Biomarkers
  • HRP-2 antigen, Plasmodium falciparum
  • Protozoan Proteins
  • Antigens, Protozoan (blood)
  • Biomarkers (blood)
  • Child
  • Disease Progression
  • Humans
  • Malaria, Cerebral (diagnosis)
  • Malaria, Falciparum (complications)
  • Malawi
  • Plasma (chemistry)
  • Protozoan Proteins (blood)
  • Sensitivity and Specificity

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