Fatal barium chloride poisoning: four cases report and literature review.

Abstract

Barium is an alkaline earth metal which has a variety of uses including in the manufacturing industry and in medicine. However, adverse health effects and fatalities occur due to absorption of soluble barium compounds, notably the chloride, nitrate, and hydroxide, which are toxic to humans. Although rare, accidental and suicidal modes of poisoning are sporadically reported in the literature.We describe 4 cases of poisoning due to barium chloride in China. In witnessed cases, severe gastrointestinal symptoms, hypokalemia leading to muscle weakness, cardiac arrhythmias, and respiratory failure were noted. Autopsy showed some nonspecific but common findings, such as subendocardial hemorrhage in the ventricles, visceral petechiae, and fatty changes in the liver. Interestingly, microscopic examination showed degenerative changes and amorphous, flocculent foamy materials in the renal tubules. Toxicology was relevant for barium in blood and tissues. Three of the cases were accidental and 1 homicidal in nature. A round-up of relevant literature on fatal barium compounds poisoning is also provided. Forensic pathologists should be aware of the clinical presentations of barium compound poisoning and especially look for any evidence of hypokalemia. Still, postmortem toxicological and histological studies are essential for an accurate identification of the cause of death.

• Authors: Sunnassee Ananda, Zhu Shaohua, Liu Liang
• Journal: The American journal of forensic medicine and pathology (Am J Forensic Med Pathol) Vol. 34 Issue 2 Pg. 115-8 (Jun 2013) ISSN: 1533-404X [Electronic] United States
• PMID: 23629399 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Barium Compounds
• Chlorides
• barium chloride

Topics

• Accidents
• Adult
• Arrhythmias, Cardiac (chemically induced)
• Barium Compounds (analysis, poisoning)
• Chlorides (analysis, poisoning)
• Diarrhea (chemically induced)
• Fatty Liver (pathology)
• Forensic Pathology
• Forensic Toxicology
• Heart Ventricles (pathology)
• Hemorrhage (pathology)
• Homicide
• Humans
• Hypokalemia (chemically induced)
• Kidney Tubules (pathology)
• Male
• Muscle Weakness (chemically induced)
• Myocardium (pathology)
• Purpura (pathology)
• Respiratory Insufficiency (chemically induced)
• Vacuoles (pathology)
• Vomiting (chemically induced)
• Young Adult