Abstract |
Pneumonia is most problematic for children in developing countries. In 2010, Brazil introduced a 10-valent pneumococcal conjugate vaccine ( PCV10) to its National Immunization Program. To assess the vaccine's effectiveness for preventing pneumonia, we analyzed rates of hospitalization among children 2-24 months of age who had pneumonia from all causes from January 2005 through August 2011. We used data from the National Hospitalization Information System to conduct an interrupted time-series analysis for 5 cities in Brazil that had good data quality and high PCV10 vaccination coverage. Of the 197,975 hospitalizations analyzed, 30% were for pneumonia. Significant declines in hospitalizations for pneumonia were noted in Belo Horizonte (28.7%), Curitiba (23.3%), and Recife (27.4%) but not in São Paulo and Porto Alegre. However, in the latter 2 cities, vaccination coverage was less than that in the former 3. Overall, 1 year after introduction of PCV10, hospitalizations of children for pneumonia were reduced.
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Authors | Eliane Terezinha Afonso, Ruth Minamisava, Ana Luiza Bierrenbach, Juan Jose Cortez Escalante, Airlane Pereira Alencar, Carla Magda Domingues, Otaliba Libanio Morais-Neto, Cristiana Maria Toscano, Ana Lucia Andrade |
Journal | Emerging infectious diseases
(Emerg Infect Dis)
Vol. 19
Issue 4
Pg. 589-97
(Apr 2013)
ISSN: 1080-6059 [Electronic] United States |
PMID | 23628462
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 10-valent pneumococcal vaccine
- Pneumococcal Vaccines
- Vaccines, Conjugate
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Topics |
- Brazil
(epidemiology)
- Child, Preschool
- Cost-Benefit Analysis
- Female
- Hospitalization
(statistics & numerical data)
- Humans
- Immunization Programs
(economics)
- Infant
- Male
- Pneumococcal Vaccines
(administration & dosage, economics, immunology)
- Pneumonia, Pneumococcal
(immunology, microbiology, prevention & control)
- Streptococcus pneumoniae
(isolation & purification)
- Urban Population
- Vaccination
- Vaccines, Conjugate
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