[Characteristics of 4 specific target antigens in adult acute lymphoblastic leukemia].

Abstract

This study was aimed to investigate clinical and prognostic significances of 4 target antigens (CD19, CD20, CD22 and CD33) for antibody-based immunotherapy and to evaluate the applications of these antibody-based target therapy to adult acute lymphoblastic leukemia (ALL). The immunophenotype of 220 adult patients with ALL were analyzed by four-color flow Cytometry, and cytogenetic and molecular parameters were detected by conventional cytogenetics, fluorescence in situ hybridization, real-time quantitative PCR, nested PCR and DNA sequencing. The results showed that CD19 positive (CD19(+)) cases were more in female (46.4% vs. 23.4%, P = 0.006), elderly patients aged > 60 years (14.4% vs. 2.1%, P = 0.022), CD33(+) co-expression cases (47.8% vs. 12.0%, P = 0.001) and genetic high-risk group (55.8% vs. 20.8%, P = 0.002) compared with CD19 negative (CD19(-)) cases; CD20(+) cases had lower co-expression of CD13 than CD20(-) cases (31.6% vs.67.1%, P = 0.000) and no significant prognostic indications for CD20(+) was observed; CD22(+) cases had higher relapse rate at 12-month than CD22(-) cases (93.9% vs.57.1%, P = 0.041) in B-ALL patients; CD33(+) cases had higher incidence of Ph(+) than CD33(-) cases (43.5% vs.19.4%, P = 0.007) and significantly correlated with Ph(+) (r = 0.261, P = 0.006). It is concluded that elucidation of the characteristics of the target antigens (CD19, CD20, CD22, CD33) used for antibody-based immunotherapy will help hematologists making the correct decision whether and when to use these antibody-based target therapies.

• Authors: Zhong-Kun Lin, Run Zhang, Zheng Ge, Juan Liu, Yu-Jie Wu, Xing Guo, Chun Qiao, Hai-Rong Qiu, Jian-Yong Li
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 21 Issue 2 Pg. 289-95 (Apr 2013) ISSN: 1009-2137 [Print] China
• PMID: 23628018 (Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antigens, CD19
• Antigens, CD20
• Sialic Acid Binding Ig-like Lectin 2
• Sialic Acid Binding Ig-like Lectin 3

Topics

• Adolescent
• Adult
• Aged
• Antigens, CD19 (immunology)
• Antigens, CD20 (immunology)
• Child
• Female
• Humans
• Immunophenotyping
• Male
• Middle Aged
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (genetics, immunology)
• Sialic Acid Binding Ig-like Lectin 2 (immunology)
• Sialic Acid Binding Ig-like Lectin 3 (immunology)
• Young Adult