Sciadopitysin: active component from Taxus chinensis for anti-Alzheimer's disease.

Abstract

Five taxane diterpenoids derived from the 95% ethanol extract of Taxus chinensis were tested for the inhibitory activities on amyloid-beta (Aβ) peptide aggregation. Using thioflavin-T fluorescence assay, sciadopitysin was found to exhibit the most potency against Aβ aggregation and the formation of fibrils. Further cellular assay indicated that sciadopitysin increased the cell viability of SH-SY5Y cell and demonstrated neuroprotection against Aβ protein-induced insult in primary cortical neurons. According to the authors' best knowledge, this is the first report that sciadopitysin can inhibit the Aβ aggregation and reduce Aβ-induced toxicity in the primary cortical neurons.

• Authors: Qiong Gu, Yanping Li, Yingchun Chen, Peifen Yao, Tianmiao Ou
• Journal: Natural product research (Nat Prod Res) Vol. 27 Issue 22 Pg. 2157-60 ( 2013) ISSN: 1478-6427 [Electronic] England
• PMID: 23627438 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid beta-Peptides
• Biflavonoids
• Neuroprotective Agents
• sciadopitysin

Topics

• Alzheimer Disease (drug therapy)
• Amyloid beta-Peptides (antagonists & inhibitors)
• Biflavonoids (isolation & purification, pharmacology, therapeutic use)
• Cell Line
• Drug Evaluation, Preclinical
• Humans
• Neurons (drug effects)
• Neuroprotective Agents (isolation & purification, pharmacology, therapeutic use)
• Taxus (chemistry)
• Toxicity Tests