HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Anti-inflammatory and analgesic activities of the hydrolyzed sasanquasaponins from the defatted seeds of Camellia oleifera.

Abstract
The defatted seeds of Camellia oleifera (Abel.) are used for stopping itching and pain in old days, the effective compounds need to be investigated. Sasanquasaponin as a rich fraction was extracted with 70% ethanol, purified by AB-8 macro-reticular resin, crystallized in 80% ethanol, and further hydrolyzed by 4% hydroxyl potassium or 2 M hydrochloride. Anti-inflammatory activities of the extracts were measured by carrageenan-induced paw edema in rats and croton oil induced ear inflammation in mice; the analgesic activities were analyzed by hot plate test, acetic acid induced writhing in mice; the levels of pain mediators of IL-1β, TNF-α and PGE₂ were determined; the antioxidative activities in vivo were evaluated by MDA, SOD and GSH-Px in serum of rats. The extracts showed significant (p < 0.01) anti-inflammatory and analgesic activities, remarkably (p < 0.01) inhibited production of pro-inflammatory cytokines and PGE2, decreased MDA and increased SOD and GSH-Px in serum. Inhibition of IL-1β, TNF-α and PGE2 may contribute to their anti-inflammatory and analgesic effects; elimination of free radicals is also involved. The sapogenin and acid hydrolyzed product have better anti-inflammatory, analgesic effects, and stronger antioxidative activity than sasanquasaponin and alkaline hydrolyzed product, and they are better candidate medicines for inflammation and pain.
AuthorsYong Ye, Haiting Xing, Xuelan Chen
JournalArchives of pharmacal research (Arch Pharm Res) Vol. 36 Issue 8 Pg. 941-51 (Aug 2013) ISSN: 0253-6269 [Print] Korea (South)
PMID23625174 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 22-O-angeloylcamelliagenin C-3-O-(glucopyranosyl-1-2)(glucopyranosyl-1-2-O-arabinopyranosyl-1-3-)glucopyranosiduronic acid
  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Drugs, Chinese Herbal
  • Saponins
Topics
  • Analgesics (chemistry, isolation & purification, therapeutic use)
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (chemistry, isolation & purification, therapeutic use)
  • Camellia
  • Drugs, Chinese Herbal (chemistry, isolation & purification, therapeutic use)
  • Edema (drug therapy, pathology)
  • Female
  • Hydrolysis
  • Male
  • Mice
  • Pain (drug therapy, pathology)
  • Rats
  • Rats, Wistar
  • Saponins (chemistry, isolation & purification, therapeutic use)
  • Seeds

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: