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Synthesis, characterization and cytotoxic activity on breast cancer cells of new half-titanocene derivatives.

Abstract
A series of novel titanocene-complexes has been prepared and evaluated for their growth regulatory effects in MCF7 and SkBr3 breast cancer cells. The capability of some of these compound to elicit relevant repressive effects on cancer cell growth could be taken into account towards novel pharmacological approaches in cancer therapy.
AuthorsEsther Sirignano, Carmela Saturnino, Antonio Botta, Maria Stefania Sinicropi, Anna Caruso, Assunta Pisano, Rosamaria Lappano, Marcello Maggiolini, Pasquale Longo
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 23 Issue 11 Pg. 3458-62 (Jun 01 2013) ISSN: 1464-3405 [Electronic] England
PMID23623493 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Organometallic Compounds
  • titanocene
Topics
  • Antineoplastic Agents (chemical synthesis, therapeutic use, toxicity)
  • Breast Neoplasms (drug therapy)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Drug Screening Assays, Antitumor
  • Female
  • Humans
  • MCF-7 Cells
  • Organometallic Compounds (chemistry, therapeutic use, toxicity)

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