Abstract | BACKGROUND: METHODS: A total of 34 patients with MPS II were enrolled to receive ERT with Elaprase(®) at a dose of 0.5 mg/kg intravenously once a week. Information regarding the symptoms, frequency, and timing of anaphylaxis during treatment was analyzed. Presence of anti- idursulfase IgE antibody was assessed by skin prick test (SPT) and enzyme-linked immunosorbent assay (ELISA). Western blotting was performed to confirm the reaction between idursulfase and specific IgE. RESULTS: Three patients (8.8%) showed anaphylaxis by infusion of idursulfase. No deaths occurred during the study. Anti- idursulfase IgE antibody was detected by SPT and ELISA. Immunoblotting with patients' sera and Elaprase(®) showed a single band of specific IgE binding to the protein around 70 kD, and idursulfase did not display amino acid sequence homology to known allergens. SPT with idursulfase demonstrated positive results in all patients with anaphylaxis. However, we failed to reveal any risk factors for the development of infusion-related immediate-type allergic reactions. CONCLUSIONS:
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Authors | J Kim, M R Park, D S Kim, J O Lee, S H Maeng, S Y Cho, Y Han, K Ahn, D K Jin |
Journal | Allergy
(Allergy)
Vol. 68
Issue 6
Pg. 796-802
(Jun 2013)
ISSN: 1398-9995 [Electronic] Denmark |
PMID | 23621439
(Publication Type: Evaluation Study, Journal Article)
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Copyright | © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Biomarkers
- Immunoglobulin E
- Iduronate Sulfatase
- idursulfase
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Topics |
- Adolescent
- Adult
- Anaphylaxis
(chemically induced, diagnosis, immunology)
- Biomarkers
(metabolism)
- Blotting, Western
- Child
- Child, Preschool
- Drug Administration Schedule
- Drug Hypersensitivity
(diagnosis, etiology, immunology)
- Enzyme Replacement Therapy
(adverse effects, methods)
- Enzyme-Linked Immunosorbent Assay
- Humans
- Iduronate Sulfatase
(adverse effects, immunology, therapeutic use)
- Immunoglobulin E
(metabolism)
- Infusions, Intravenous
- Male
- Mucopolysaccharidosis II
(drug therapy, immunology)
- Risk Factors
- Skin Tests
- Treatment Outcome
- Young Adult
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