Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine.

Abstract

Despite the fact that advances of burn treatment have led to reduction in the morbidity caused by burns, burn infection is still a serious problem. In this study, we designed blended synthetic and natural polymers nanofiber scaffolds using polyurethane (PU) and gelatin, which were prepared by an electrospinning method. Silver-sulfadiazine (SSD) was co-mixed to the blended polymer solution for being incorporated into the nanofibers after the electrospinning, followed by examination of burn-wound healing effect. The nanofiber scaffolds containing SSD should not only serve as a substrate for skin regeneration, but may also deliver suitable drugs, within a controlled manner during healing. The SSD release was able to prevent the growth of a wide array of bacteria and accelerate the wound healing by preventing infection. Therefore it could accelerate the burn-wound closure rate. We confirmed that PU/gelatin nanofiber scaffolds containing SSD lead to enhanced regeneration of burn-wounds.

• Authors: Dong Nyoung Heo, Dae Hyeok Yang, Jung Bok Lee, Min Soo Bae, Jung Ho Kim, Seong Hwan Moon, Heoung Jae Chun, Chun Ho Kim, Ho-Nam Lim, Il Keun Kwon
• Journal: Journal of biomedical nanotechnology (J Biomed Nanotechnol) Vol. 9 Issue 3 Pg. 511-5 (Mar 2013) ISSN: 1550-7033 [Print] United States
• PMID: 23621008 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Polyurethanes
• Gelatin
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9
• Silver Sulfadiazine

Topics

• Animals
• Burns (drug therapy, enzymology, pathology)
• Cattle
• Gelatin (chemistry)
• Male
• Matrix Metalloproteinase 2 (metabolism)
• Matrix Metalloproteinase 9 (metabolism)
• Nanofibers (chemistry)
• Polyurethanes (chemistry)
• Rats
• Rats, Sprague-Dawley
• Silver Sulfadiazine (pharmacology, therapeutic use)
• Tissue Scaffolds (chemistry)
• Wound Healing (drug effects)