Abstract | OBJECTIVES: This study investigated the influence of virological response (VR) to entecavir on clinical liver disease progression in nucleos(t)ide analogue (NA)-naive and -experienced patients. METHODS: RESULTS: Of the 487 patients, 49 developed clinical events during entecavir treatment. Of those, 36 developed HCC. For all patients, Cox regression analysis showed that age, baseline cirrhosis, alanine aminotransferase level ≤200 U/L, albumin level and no VR during entecavir treatment were independent predictors for clinical events and HCC development. However, the benefit of VR to entecavir was significant for clinical events and HCC only in NA-experienced patients, but not in NA-naive patients. For the further analysis of the different subgroups of NA-experienced patients, the benefit of VR to entecavir was significant for clinical events or HCC only in patients with prior lamivudine- or adefovir-resistant mutants, but not in NA-experienced patients who had never developed lamivudine- or adefovir-resistant mutants. VR at month 12 (but not early VR at month 6) remained a significant predictor associated with the development of clinical events and HCC in NA-experienced patients. CONCLUSIONS: VR to entecavir was associated with a reduced risk of clinical events and HCC in NA-experienced patients, particularly in those who had prior lamivudine- or adefovir-resistant mutants.
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Authors | Shih-Cheng Yang, Chuan-Mo Lee, Tsung-Hui Hu, Jing-Houng Wang, Sheng-Nan Lu, Chao-Hung Hung, Chi-Sin Changchien, Chien-Hung Chen |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 68
Issue 9
Pg. 2154-63
(Sep 2013)
ISSN: 1460-2091 [Electronic] England |
PMID | 23620466
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antiviral Agents
- DNA, Viral
- entecavir
- Guanine
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Topics |
- Adult
- Aged
- Antiviral Agents
(therapeutic use)
- Carcinoma, Hepatocellular
(epidemiology, prevention & control)
- DNA, Viral
(blood)
- Drug Resistance, Viral
- Female
- Guanine
(analogs & derivatives, therapeutic use)
- Hepatitis B virus
(drug effects)
- Hepatitis B, Chronic
(complications, drug therapy)
- Humans
- Liver Cirrhosis
(epidemiology, prevention & control)
- Liver Neoplasms
(epidemiology, prevention & control)
- Male
- Middle Aged
- Risk Assessment
- Treatment Outcome
- Viral Load
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