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Periocular triamcinolone acetonide injections for control of intraocular inflammation associated with uveitis.

AbstractPURPOSE:
To describe the effectiveness of periocular corticosteroid injections for the control of intraocular inflammation associated with noninfectious uveitis.
METHODS:
A total of 81 patients (109 eyes) who received a periocular injection were evaluated for active inflammation, visual acuity, intraocular pressure, degree of intraocular inflammation, and the presence of ocular complications, including macular edema.
RESULTS:
Of all eyes, 36% (95%CI: 25%, 45%) demonstrated clinical resolution of inflammation at the 1-month visit after first injection, and 48% (95%CI: 37%, 59%) at 3 months. For multiple injections, 50% (95%CI: 28%, 72%) demonstrated resolution of inflammation at 1 month after the last injection, and 41% (95%CI: 20%, 63%) resolution of inflammation at 3 months after the last injection. Of the 49 eyes that initially responded, the estimated median time to recurrence was 7.6 months.
CONCLUSIONS:
Approximately half of the treated eyes had resolution of intraocular inflammation at 3 months after corticosteroid injection.
AuthorsSherveen S Salek, Henry A Leder, Nicholas J Butler, Theresa J Gan, James P Dunn, Jennifer E Thorne
JournalOcular immunology and inflammation (Ocul Immunol Inflamm) Vol. 21 Issue 4 Pg. 257-63 (Aug 2013) ISSN: 1744-5078 [Electronic] England
PMID23617776 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Glucocorticoids
  • Triamcinolone Acetonide
Topics
  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Glucocorticoids (administration & dosage)
  • Humans
  • Injections, Intraocular
  • Male
  • Middle Aged
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome
  • Triamcinolone Acetonide (administration & dosage)
  • Uveitis (drug therapy, physiopathology)
  • Visual Acuity
  • Young Adult

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