[Effects of Yougui recipe on the behavioral changes in rat of steroid-induced avascular necrosis of the femoral head].

Abstract

OBJECTIVE:

To explore the effect of Yougui Recipe, a kidney-supplementing and yang-activating formula which on the behavioral changes of rat of steroid-induced avascular necrosis of the femoral head (SANFH).

METHODS:

Thirty Wistar rats were involved and were randomly divided into the blank control group (group A), the model group (group B) and the Yougui Recipe group (group C). SANFH models were established by injection of colibacillus endotoxin and prednisolone intramuscularly. Group C was lavaged with Yougui Recipe (10 ml/kg), while group A and group B were lavaged with the same amount of saline. The behavior of catch force, independent activities, the tail suspension, field experiment and water cleans maze experiment were observed after 6 weeks.

RESULTS:

Compared with Yougui Recipe, rats in model group: catch force and independent activity decreases; the tail suspension activities was less time. In the desert field experiments, the total distance in 10 min movement reduced significantly. In the water maze experiment, incubation period of escape had a long time obviously, total distance of activities reduced.

CONCLUSION:

Yougui Recipe can relieve the ethologic change of rat model of steroid-induced avascular necrosis of the femoral head.

• Authors: Miao-Feng Hu, Xiao-Cheng Zhou, Le-Tian Shan, Lu-Wei Xiao, Pei-Jian Tong
• Journal: Zhongguo gu shang = China journal of orthopaedics and traumatology (Zhongguo Gu Shang) Vol. 26 Issue 1 Pg. 50-3 (Jan 2013) ISSN: 1003-0034 [Print] China
• PMID: 23617143 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenal Cortex Hormones
• Drugs, Chinese Herbal

Topics

• Adrenal Cortex Hormones (toxicity)
• Animals
• Drugs, Chinese Herbal (pharmacology)
• Femur Head Necrosis (chemically induced, psychology)
• Hindlimb Suspension
• Male
• Maze Learning (drug effects)
• Motor Activity (drug effects)
• Rats
• Rats, Wistar