Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells.

Abstract

Growing evidence suggests that the flavonoid epigallocatechin-3-gallate (EGCG), notably abundant in green tea, has health-promoting properties. We examined the effect of EGCG on cell survival and apoptosis in the prostate cancer cell line PC3. Cell survival was reduced and apoptosis increased significantly with a low dose of 1 µM EGCG. The ability of the anticancer drug cisplatin to promote apoptosis was enhanced by EGCG. Furthermore, EGCG, both alone and in combination with cisplatin, promoted the expression of the pro-apoptotic splice isoform of caspase 9.

• Authors: Rachel M Hagen, Veronica S Chedea, Christopher P Mintoff, Elizabeth Bowler, H Ruth Morse, Michael R Ladomery
• Journal: International journal of oncology (Int J Oncol) Vol. 43 Issue 1 Pg. 194-200 (Jul 2013) ISSN: 1791-2423 [Electronic] Greece
• PMID: 23615977 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Protein Isoforms
• Catechin
• epigallocatechin gallate
• Caspase 9
• Cisplatin

Topics

• Apoptosis (drug effects)
• Caspase 9 (biosynthesis, genetics)
• Catechin (analogs & derivatives, pharmacology)
• Cell Line, Tumor
• Cisplatin (pharmacology)
• Gene Expression Regulation, Neoplastic (drug effects)
• Humans
• Male
• Prostatic Neoplasms (drug therapy, genetics, pathology)
• Protein Isoforms (genetics)