Abstract | OBJECTIVE: METHODS: A Markov model was developed to estimate the cost-effectiveness of intramuscular interferon beta-1a (IM IFNβ-1a), subcutaneous interferon beta-1a (SC IFNβ-1a), interferon beta-1b (IFNβ-1b) and glatiramer acetate (GA) relative to best supportive care in a hypothetical cohort of 1,000 RRMS patients in Spain. The model was developed from a societal perspective with a time horizon of 30 years. Natural history and clinical trial data were used to model relapse rates and disease progression. Cost and utility data were obtained from a published survey of multiple sclerosis patients in Spain. The primary outcome measure was cost per quality-adjusted life year (QALY) gained. Univariate and probabilistic sensitivity analyses were performed. RESULTS: Compared to best supportive care, the base case cost-effectiveness was <euro>168,629 per QALY gained for IM IFNβ-1a, <euro>231,853 per QALY gained for IFNβ-1b, <euro>295,638 per QALY gained for SC IFNβ-1a, and <euro>318,818 per QALY gained for GA. Results were most sensitive to changes in DMT cost, utility values and treatment effect. CONCLUSIONS: In our cost-effectiveness analysis of first-line injectable DMTs in Spain, we found IM IFNβ-1a to be more cost-effective than SC IFNβ-1a, IFNβ-1b or GA. Sensitivity analyses confirmed the robustness of these results.
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Authors | Carole Dembek, Leigh Ann White, Jayson Quach, Andrea Szkurhan, Nazia Rashid, M R Blasco |
Journal | The European journal of health economics : HEPAC : health economics in prevention and care
(Eur J Health Econ)
Vol. 15
Issue 4
Pg. 353-62
(May 2014)
ISSN: 1618-7601 [Electronic] Germany |
PMID | 23615954
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adjuvants, Immunologic
- Interferon beta-1b
- Interferon-beta
- Interferon beta-1a
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Topics |
- Adjuvants, Immunologic
(administration & dosage, economics)
- Adult
- Cost-Benefit Analysis
- Female
- Humans
- Injections
- Interferon beta-1a
- Interferon beta-1b
- Interferon-beta
(administration & dosage, economics)
- Male
- Markov Chains
- Middle Aged
- Models, Economic
- Multiple Sclerosis, Relapsing-Remitting
(drug therapy, economics)
- Quality-Adjusted Life Years
- Treatment Outcome
- Young Adult
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