Investigation of possible epistatic interactions between GRIA2 and GRIA4 variants on clinical outcomes in patients with major depressive disorder.

Abstract

OBJECTIVES:

To investigate the effects of glutamate receptor, ionotropic, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) 2 (GRIA2) rs4260586 and glutamate receptor, ionotropic, AMPA 4 (GRIA4) rs10736648 single nucleotide polymorphisms (SNPs) on response to antidepressants in Korean patients with major depressive disorder (MDD), and to ascertain whether epistatic interactions might exist between these SNPs.

METHODS:

In this retrospective analysis, patients were assessed at hospital admission and discharge using the Montgomery-Åsberg depression rating scale (MADRS). A multiple regression model was employed to investigate the effects of the two SNP variants on clinical/sociodemographic outcomes relating to MDD.

RESULTS:

Out of 145 Korean patients, the presence of both GRIA2 rs4260586 and GRIA4 rs10736648 polymorphisms had no significant association with MADRS improvement scores or other clinical/sociodemographic variables.

CONCLUSIONS:

These data potentially suggest a lack of epistatic interaction between GRIA2 and GRIA4 variants, regarding clinical outcomes in patients with MDD. The study was limited by small sample size, use of different antidepressants and incomplete coverage of genes under investigation. Future research should include larger patient samples treated with different antidepressants, analysis of different SNPs and/or investigation of different gene-gene interactions within the glutamatergic system.

• Authors: Alberto Chiesa, Loredana Lia, Claudia Lia, Soo-Jung Lee, Changsu Han, Ashwin A Patkar, Chi-Un Pae, Alessandro Serretti
• Journal: The Journal of international medical research (J Int Med Res) Vol. 41 Issue 3 Pg. 809-15 (Jun 2013) ISSN: 1473-2300 [Electronic] England
• PMID: 23613500 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antidepressive Agents
• Receptors, AMPA
• glutamate receptor ionotropic, AMPA 4
• glutamate receptor ionotropic, AMPA 2

Topics

• Adult
• Antidepressive Agents (therapeutic use)
• Asian People
• Depressive Disorder, Major (drug therapy, ethnology, genetics, physiopathology)
• Epistasis, Genetic
• Female
• Gene Frequency
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Psychiatric Status Rating Scales
• Receptors, AMPA (genetics)
• Retrospective Studies
• Treatment Outcome