HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

From reactivation of latent HIV-1 to elimination of the latent reservoir: the presence of multiple barriers to viral eradication.

Abstract
The discovery of a stable latent reservoir for HIV-1 in resting memory CD4(+) T cells provides a mechanism for lifelong persistence of HIV-1. The long-lived latently infected cells persist in spite of prolonged highly active antiretroviral therapy and present a major barrier to a cure of HIV-1 infection. In this review, we discuss the current understanding of HIV-1 persistence and latent viral infection in the context of effective antiretroviral therapy and the recent progress in purging latent viral reservoirs. Recent studies demonstrate that reactivation of latent HIV-1 is a promising strategy for the depletion of these viral reservoirs. A thorough evaluation of the anti-latency activity of drug candidates should include the measurement of changes in intracellular viral RNA, plasma virus levels, and the size of latent viral reservoirs, as well as potential adverse effects. Currently, there are several technical barriers to the evaluation of anti-latency drugs in vivo. We also discuss these challenging issues that remain unresolved.
AuthorsLiang Shan, Robert F Siliciano
JournalBioEssays : news and reviews in molecular, cellular and developmental biology (Bioessays) Vol. 35 Issue 6 Pg. 544-52 (Jun 2013) ISSN: 1521-1878 [Electronic] United States
PMID23613347 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Copyright© 2013 WILEY Periodicals, Inc.
Chemical References
  • Anti-HIV Agents
Topics
  • Anti-HIV Agents (administration & dosage, pharmacology)
  • Antiretroviral Therapy, Highly Active
  • CD4-Positive T-Lymphocytes (virology)
  • HIV Infections (drug therapy, immunology, virology)
  • HIV-1 (physiology)
  • Humans
  • Virus Activation
  • Virus Latency (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: