Abstract | PURPOSE: MATERIAL/METHODS: Diagnosis of cow's milk allergy was established by a medical history of symptoms associated with exposure to cow's milk, positive skin prick tests with cow's milk, the presence of milk-specific IgE, and by a positive double- or single-blind placebo-controlled food challenge with milk confirmed by a positive open-controlled milk challenge. A second oral challenge was performed after at least one year of a milk-free diet and children with a positive oral milk rechallenge were diagnosed as having a persistent CMA. RESULTS: Two hundred ninety-one children, 2-14 years of age (mean 5.30±3.16 years, 95% CI, 5.02-5.62 years) completed the study. Persistent CMA was diagnosed in 79 patients (27.1%). Two hundred twelve children (72.9%) outgrew their allergy to cow's milk at a mean age of 5 years after an average time of 16.4±0.8 months on an elimination diet. Eighty percent of children below 3 years of age became milk tolerant. Milk-specific IgE (p=0.018) and history of paternal bronchial asthma and/or rhinitis (p=0.020) were associated with persistence of cow's milk allergy in regression analysis. CONCLUSIONS: An age above 3 years, as well as features of atopy, individual and familial, may be associated with a risk of delayed tolerance to milk in children.
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Authors | M Kaczmarski, J Wasilewska, B Cudowska, J Semeniuk, M Klukowski, E Matuszewska |
Journal | Advances in medical sciences
(Adv Med Sci)
Vol. 58
Issue 1
Pg. 22-30
( 2013)
ISSN: 1898-4002 [Electronic] Netherlands |
PMID | 23612699
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Milk Proteins
- Immunoglobulin E
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Topics |
- Adolescent
- Animals
- Cattle
- Child
- Child, Preschool
- Diet
- Double-Blind Method
- Female
- Humans
- Immunoglobulin E
(immunology)
- Male
- Milk
- Milk Hypersensitivity
(diagnosis, epidemiology)
- Milk Proteins
- Poland
- Prevalence
- Prospective Studies
- Regression Analysis
- Single-Blind Method
- Skin Tests
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