The functional MICA-129 polymorphism is associated with skin but not joint manifestations of psoriatic disease independently of HLA-B and HLA-C.

Abstract

A methionine/valine polymorphism at amino acid 129 of the major histocompatibility complex class I chain-related gene A (MICA-129) categorizes alleles into strong and weak binders of the natural killer (NK) and T-cell receptor NKG2D. We investigated whether MICA-129 is differentially associated with skin and joint manifestations of psoriatic disease (PsD) independently of human leukocyte antigen (HLA)-C and HLA-B in patients and controls from Toronto and St. John's. The MICA-129 methionine (Met) allele, particularly Met/Met homozygosity, was strongly associated with both cutaneous psoriasis (PsC) and psoriatic arthritis (PsA) independently of HLA-B and HLA-C in Toronto patients, and was also associated with PsA in St. John's patients, but with no additional effect of Met/Met homozygosity. No association remained after adjustment for HLA alleles in St. John's patients. MICA-129 was not associated with PsA when compared with PsC. We conclude that MICA-129 is a marker of skin manifestations of PsD that is independent of HLA class I in Toronto patients.

• Authors: R A Pollock, V Chandran, F J Pellett, A Thavaneswaran, L Eder, J Barrett, P Rahman, V Farewell, D D Gladman
• Journal: Tissue antigens (Tissue Antigens) Vol. 82 Issue 1 Pg. 43-7 (Jul 2013) ISSN: 1399-0039 [Electronic] England
• PMID: 23611695 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• HLA-B Antigens
• HLA-C Antigens
• Histocompatibility Antigens Class I
• MHC class I-related chain A

Topics

• Adult
• Case-Control Studies
• Demography
• Female
• Gene Frequency (genetics)
• Genetic Predisposition to Disease
• HLA-B Antigens
• HLA-C Antigens (immunology)
• Histocompatibility Antigens Class I (genetics)
• Homozygote
• Humans
• Joints (pathology)
• Logistic Models
• Male
• Multivariate Analysis
• Polymorphism, Single Nucleotide (genetics)
• Psoriasis (genetics, immunology)
• Skin (pathology)