Abstract |
In this case report, we describe a patient with Dercum's disease who was successfully managed with metformin. The administration of metformin reduced pain intensity from 9/10 to 3/10 and favorably affected the profile of inflammatory cytokines (i.e., TNF a, IL-1β, IL-6, and IL-10), adipokines (i.e., adiponectin, leptin, and resistin), and β- endorphin. Because each variable was affected moderately by the drug, in the range of 20 - 30%, it follows that these effects are additive, i.e., they act independently of each other. However, taking into account advances in the pharmacology of metformin, it seems that other phenomena, such as modulation of synaptic plasticity, activation of microglia, and autophagy of the afferents supplying painful lipomas should be taken into consideration. Nonetheless, metformin deserves further exploration in the biology of pain.
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Authors | Krzysztof Łabuzek, Sebastian Liber, Dariusz Suchy, Bogusław Okopień |
Journal | International journal of clinical pharmacology and therapeutics
(Int J Clin Pharmacol Ther)
Vol. 51
Issue 6
Pg. 517-24
(Jun 2013)
ISSN: 0946-1965 [Print] Germany |
PMID | 23611575
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Cytokines
- Hypoglycemic Agents
- Metformin
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Topics |
- Adiposis Dolorosa
(complications, drug therapy, immunology)
- Cytokines
(blood)
- Diabetes Mellitus, Type 2
(complications, drug therapy, immunology)
- Humans
- Hypoglycemic Agents
(administration & dosage, therapeutic use)
- Male
- Metformin
(administration & dosage, therapeutic use)
- Middle Aged
- Neuralgia
(drug therapy, etiology, immunology)
- Pain Management
(methods)
- Treatment Outcome
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